Jonas Widmer

Dr. Jonas Widmer obtained his doctorate in the field of experimental and computational research in the field of spine biomechanics in 2020. Besides the academic activity, he is involved in the research and development of diverse and novel spine implants with the startup company 25Segments. Dr. Jonas Widmer has been the head of Spine Biomechanics group at Balgrist University Hospital since November 2020. 

PUBLICATIONS

ORIGINAL PAPERS

  • Balzer, I., Mühlemann, M., Jokeit, M., Rawal, I.S., Snedeker, J.G., Farshad, M., Widmer, J., 2022. A deep learning pipeline for automatized assessment of spinal MRI. Computer Methods and Programs in Biomedicine Update 2, 100081. https://doi.org/10.1016/j.cmpbup.2022.100081
  • Bernal, L.M.B., Schmidt, I.T., Vulin, N., Widmer, J., Snedeker, J.G., Cattin, P.C., Zam, A., Rauter, G., 2018. Optimizing controlled laser cutting of hard tissue (bone). at - Automatisierungstechnik 66, 1072–1082. https://doi.org/10.1515/auto-2018-0072
  • Burkhard, M.D., Cornaz, F., Spirig, J.M., Wanivenhaus, F., Loucas, R., Fasser, M.-R., Widmer, J., Farshad, M., 2021. Posterior spinal instrumentation and decompression with or without cross-link? North American Spine Society Journal (NASSJ) 8, 100093. https://doi.org/10.1016/j.xnsj.2021.100093
  • Caprara, S., Carrillo, F., Snedeker, J.G., Farshad, M., Senteler, M., 2021. Automated Pipeline to Generate Anatomically Accurate Patient-Specific Biomechanical Models of Healthy and Pathological FSUs. Front. Bioeng. Biotechnol. 9. https://doi.org/10.3389/fbioe.2021.636953
  • Caprara, S., Fasser, M.-R., Spirig, J.M., Widmer, J., Snedeker, J.G., Farshad, M., Senteler, M., 2022. Bone density optimized pedicle screw instrumentation improves screw pull-out force in lumbar vertebrae. Computer Methods in Biomechanics and Biomedical Engineering 25, 464–474. https://doi.org/10.1080/10255842.2021.1959558
  • Cornaz, F., Burkhard, M., Fasser, M.-R., Spirig, J.M., Snedeker, J.G., Farshad, M., Widmer, J., 2021a. 3D printed clamps for fixation of spinal segments in biomechanical testing. Journal of Biomechanics 125, 110577. https://doi.org/10.1016/j.jbiomech.2021.110577
  • Cornaz, F., Farshad, M., Widmer, J., 2022a. Location of pedicle screw hold in relation to bone quality and loads. Frontiers in Bioengineering and Biotechnology 10.
  • Cornaz, F., Fasser, M.-R., Snedeker, J.G., Spirig, J.M., Farshad, M., Widmer, J., 2022b. The biomechanical fundamentals of crosslink-augmentation in posterior spinal instrumentation. Sci Rep 12, 7621. https://doi.org/10.1038/s41598-022-11719-2
  • Cornaz, F., Fasser, M.-R., Spirig, J.M., Snedeker, J.G., Farshad, M., Widmer, J., 2020. 3D printed clamps improve spine specimen fixation in biomechanical testing. J Biomech 98, 109467. https://doi.org/10.1016/j.jbiomech.2019.109467
  • Cornaz, F., Haupt, S., Farshad, M., Widmer, J., 2022c. Real-time assessment of anteroposterior stability of spinal segments. Eur Spine J 31, 2368–2376. https://doi.org/10.1007/s00586-022-07286-9
  • Cornaz, F., Widmer, J., Farshad-Amacker, N.A., Spirig, J.M., Snedeker, J.G., Farshad, M., 2021b. Biomechanical Contributions of Spinal Structures with Different Degrees of Disc Degeneration. Spine Publish Ahead of Print. https://doi.org/10.1097/BRS.0000000000003883
  • Cornaz, F., Widmer, J., Farshad-Amacker, N.A., Spirig, J.M., Snedeker, J.G., Farshad, M., 2021c. Intervertebral disc degeneration relates to biomechanical changes of spinal ligaments. The Spine Journal. https://doi.org/10.1016/j.spinee.2021.04.016
  • Cornaz, F., Widmer, J., Fasser, M.-R., Snedeker, J.G., Matsukawa, K., Spirig, J.M., Farshad, M., 2021d. Is a cross-connector beneficial for single level traditional or cortical bone trajectory pedicle screw instrumentation? PLOS ONE 16, e0253076. https://doi.org/10.1371/journal.pone.0253076
  • Cornaz, F., Widmer, J., Snedeker, J.G., Spirig, J.M., Farshad, M., 2021e. Cross-links in posterior pedicle screw-rod instrumentation of the spine: a systematic review on mechanical, biomechanical, numerical and clinical studies. Eur Spine J 30, 34–49. https://doi.org/10.1007/s00586-020-06597-z
  • Farshad, M., Cornaz, F., Spirig, J.M., Sutter, R., Farshad-Amacker, N.A., Widmer, J., 2022a. Spondylophyte classification based on biomechanical effects on segmental stiffness. The Spine Journal 22, 1903–1912. https://doi.org/10.1016/j.spinee.2022.06.001
  • Farshad, M., Frey, A., Jentzsch, T., Betz, M., Widmer, J., Spirig, J.M., 2021. Reducing the kyphosis effect of anterior short thoracolumbar/lumbar scoliosis correction with an autograft fulcrum effect. BMC Musculoskeletal Disorders 22, 216. https://doi.org/10.1186/s12891-021-04083-1
  • Farshad, M., Hagel, V., Spirig, J.M., Fasser, M.-R., Widmer, J., Burkhard, M.D., Calek, A.-K., 2022b. Biomechanics of Transforaminal Endoscopic Approaches. Spine 47, 1753–1760. https://doi.org/10.1097/BRS.0000000000004471
  • Fasser, M.-R., Kuravi, R., Bulla, M., Snedeker, J.G., Farshad, M., Widmer, J., 2022b. A novel approach for tetrahedral-element-based finite element simulations of anisotropic hyperelastic intervertebral disc behavior. Frontiers in Bioengineering and Biotechnology 10.
  • Fasser, M.-R., Gerber, G., Passaplan, C., Cornaz, F., Snedeker, J.G., Farshad, M., Widmer, J., 2022. Computational model predicts risk of spinal screw loosening in patients. Eur Spine J 31, 2639–2649. https://doi.org/10.1007/s00586-022-07187-x
  • Fasser, M.-R., Jokeit, M., Kalthoff, M., Gomez Romero, D.A., Trache, T., Snedeker, J.G., Farshad, M., Widmer, J., 2021. Subject-Specific Alignment and Mass Distribution in Musculoskeletal Models of the Lumbar Spine. Frontiers in Bioengineering and Biotechnology 9.
  • Götschi, T., Widmer, J., Cornaz, F., Kimenai, J., Spirig, J.M., Snedeker, J.G., Farshad, M., 2021. Region- and degeneration dependent stiffness distribution in intervertebral discs derived by shear wave elastography. Journal of Biomechanics 121, 110395. https://doi.org/10.1016/j.jbiomech.2021.110395
  • Haupt, S., Cornaz, F., Falkowski, A.L., Widmer, J., Farshad, M., 2022. Biomechanical considerations of the posterior surgical approach to the lumbar spine. The Spine Journal. https://doi.org/10.1016/j.spinee.2022.08.006
  • Heggli, I., Laux, C.J., Mengis, T., Karol, A., Cornaz, F., Herger, N., Aradi‐Vegh, B., Widmer, J., Burkhard, M.D., Farshad‐Amacker, N.A., Pfammatter, S., Wolski, W.E., Brunner, F., Distler, O., Farshad, M., Dudli, S., 2022. Modic type 2 changes are fibroinflammatory changes with complement system involvement adjacent to degenerated vertebral endplates. JOR Spine. https://doi.org/10.1002/jsp2.1237 
  • Jokeit, M., Kim, J.H., Snedeker, J.G., Farshad, M., Widmer, J., 2022. Mesh-based 3D Reconstruction from Bi-planar Radiographs. Presented at the Medical Imaging with Deep Learning.
  • Lindenmann, S., Tsagkaris, C., Farshad, M., Widmer, J., 2022. Kinematics of the Cervical Spine Under Healthy and Degenerative Conditions: A Systematic Review. Ann Biomed Eng 50, 1705–1733. https://doi.org/10.1007/s10439-022-03088-8 
  • Roth, T., Rahm, S., Jungwirth-Weinberger, A., Süess, J., Sutter, R., Schellenberg, F., Taylor, W.R., Snedeker, J.G., Widmer, J., Zingg, P., 2021. Restoring range of motion in reduced acetabular version by increasing femoral antetorsion – What about joint load? Clinical Biomechanics 87, 105409. https://doi.org/10.1016/j.clinbiomech.2021.105409
  • Scheibler, A.-G., Götschi, T., Widmer, J., Holenstein, C., Steffen, T., Camenzind, R.S., Snedeker, J.G., Farshad, M., 2018. Feasibility of the annulus fibrosus repair with in situ gelating hydrogels – A biomechanical study. PLOS ONE 13, e0208460. https://doi.org/10.1371/journal.pone.0208460
  • Schoenenberger, A.D., Tempfer, H., Lehner, C., Egloff, J., Mauracher, M., Bird, A., Widmer, J., Maniura-Weber, K., Fucentese, S.F., Traweger, A., Silvan, U., Snedeker, J.G., 2020. Macromechanics and polycaprolactone fiber organization drive macrophage polarization and regulate inflammatory activation of tendon in vitro and in vivo. Biomaterials 249, 120034. https://doi.org/10.1016/j.biomaterials.2020.120034
  • Spirig, J.M., Winkler, E., Cornaz, F., Fasser, M.-R., Betz, M., Snedeker, J.G., Widmer, J., Farshad, M., 2021. Biomechanical performance of bicortical versus pericortical bone trajectory (CBT) pedicle screws. Eur Spine J. https://doi.org/10.1007/s00586-021-06878-1
  • Tsagkaris, C., Kalachanis, K., Widmer, J., Farshad, M., 2022a. Spine Biomechanics in the Work of Aristotle (384 – 322 BC). Surg Innov 155335062211480. https://doi.org/10.1177/15533506221148012 
  • Tsagkaris, C., Widmer, J., Wanivenhaus, F., Redaelli, A., Lamartina, C., Farshad, M., 2022. The sitting vs standing spine. North American Spine Society Journal (NASSJ) 9, 100108. https://doi.org/10.1016/j.xnsj.2022.100108
  • Widmer, J., Aubin, C.-E., van Lenthe, G.H., Matsukawa, K., 2022. Editorial: Innovations to improve screw fixation in traumatology and orthopedic surgery. Frontiers in Bioengineering and Biotechnology 10.
  • Widmer, J., Cornaz, F., Farshad-Amacker, N.A., Snedeker, J.G., Spirig, med. J.M., Farshad, M., 2021. Hydrostatic integrity of the intervertebral disc assessed by MRI. Journal of Biomechanics 127, 110661. https://doi.org/10.1016/j.jbiomech.2021.110661
  • Widmer, J., Cornaz, F., Scheibler, G., Spirig, J.M., Snedeker, J.G., Farshad, M., 2020a. Biomechanical contribution of spinal structures to stability of the lumbar spine—novel biomechanical insights. The Spine Journal 20, 1705–1716. https://doi.org/10.1016/j.spinee.2020.05.541
  • Widmer, J., Fasser, M.-R., Croci, E., Spirig, J., Snedeker, J.G., Farshad, M., 2020b. Individualized prediction of pedicle screw fixation strength with a finite element model. Computer Methods in Biomechanics and Biomedical Engineering 23, 155–167. https://doi.org/10.1080/10255842.2019.1709173
  • Widmer, J., Fornaciari, P., Senteler, M., Roth, T., Snedeker, J.G., Farshad, M., 2019. Kinematics of the Spine Under Healthy and Degenerative Conditions: A Systematic Review. Ann Biomed Eng 47, 1491–1522. https://doi.org/10.1007/s10439-019-02252-x
  • Wunderli, S.L., Widmer, J., Amrein, N., Foolen, J., Silvan, U., Leupin, O., Snedeker, J.G., 2018. Minimal mechanical load and tissue culture conditions preserve native cell phenotype and morphology in tendon-a novel ex vivo mouse explant model. Journal of Orthopaedic Research 36, 1383–1390. https://doi.org/10.1002/jor.23769